Influenza A virus induces PI4P production at the endoplasmic reticulum in an ATG16L1-dependent manner to promote the egress of viral ribonucleoproteins
Brault, et al. 2025
Voir la publicationCell Biology of Mammalian Neurogenesis
Equipe
Cell Biology of Mammalian Neurogenesis
Membres
Alexandre BAFFET (DR INSERM, group leader), Jean-Baptiste BRAULT (Assistant Professor), Amandine DI CICCO (staff engineer), Christophe Chehade (Engineer), Clarisse Brunet-Avalos (postdoctoral researcher), Ludovica Brunetti (postdoctoral researcher), Enzo Bresteau (postdoctoral researcher), Pankhuri Sinha (doctoral student), Etienne Poidomani (doctoral student), Pauline (doctoral student)
Mots clés
radial glial cells, cerebral cortex, polarised trafficking, secretion, ECM, niche, cell fate decisions, neurogenesis, gliogenesis, development.
Description
The cerebral neocortex is the center for higher cognitive functions, including perception, decision-making, and language. Our group investigates the fundamental mechanisms that drive neocortical development, with a particular focus on the role and regulation of radial glial cells—the neural stem cells of the developing cortex that give rise to the majority of its neurons and glial cells, using a combination of complementary and highly relevant model systems, ranging from neural stem cell cultures and embryonic mouse brain to iPSC-derived human cortical organoids and human fetal tissue.
Modèles biologiques
Neural stems cells, embryonic mouse brain, human cortical organoids, human fetal cortical tissue
Publications scientifiques
