Human iPSC-derived airway models enable comparative analysis of SARS-CoV-2 infection in healthy and COPD bronchial epithelium
Morichon, et al. 2026
View the publicationMembrane Domains and Virus Assembly (MDVA)
Members
Delphine Muriaux - delphine.muriaux@irim.cnrs.fr
Cyril Favard - cyril.favard@irim.cnrs.fr
Claire Lacouture - claire.lacouture@irim.cnrs.fr
Keywords
RNA enveloped viruses, virus assembly, RNA and protein-lipid interactions, VLP, exosomes, actin cytoskeleton, fluorescence microscopies
Description
Our team is interested in the role of viral and cellular proteins and their interactions with viral RNA and host cell lipids during viral translation and virus assembly.
We study these phenomena quantitatively and at the single molecule level, on biomimetic membrane model systems, in host cells and in living multicellular organisms.
Biological models
biomimetic membranes, host cell lines, primary lymphocytes, Air Liquid Interface lung models
Scientific Publications
HIV-1 diverts actin debranching mechanisms for particle assembly and release in CD4 T lymphocytes
Dibsy, et al. 2023
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F-actin nanostructures rearrangements and regulation are essential for SARS-CoV2 particle production in host pulmonary cells
Swain, et al. 2023
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