Institute of Psychiatry and Neurosciences of Paris, Inserm 1266
102 Rue de la Santé
Team
Membrane traffic in normal and diseased brain
Members
• Thierry Galli
• Lydia Danglot
• David Tareste
• Sebastien Nola
• Paul Heo
• Christian Vannier
• Paul Nazac
• David Boulet
• Anais Vlieghe
Keywords
fusion, traffic, SNAREs, mitofusin, endosome, lysosome, mitochondria, advanced microscopy (dual color dynamics, SIM, STED, STORM)
Description
Our team studies the dynamics of intracellular membranes in neurons in both normal and pathological contexts. The team’s aim is to understand the mechanisms and regulation of membrane trafficking in the context of the developing brain, brain tumors, psychiatric and degenerative diseases (Parkinson’s, Alzheimer’s). To achieve this, we use cell and molecular biology techniques, and more specifically microscopy (dynamic and super-resolution), proteomic and biophysical approaches to study membrane dynamics in vitro and in vivo.
Biological models
in vitro reconstitution of biological membranes, cell lines, primary neurons or astrocytes, organoïds