Institut Necker Enfants Malades (INEM)
156 Rue de Vaugirard
Team
Cellular & Membrane Dynamics in Stress Response (MEMBRAMICS)
Members
Dr Etienne MOREL
(INSERM DR2 / team leader, project leader)
etienne.morel@inserm.fr
Dr Aurore CLAUDE-TAUPIN
(INSERM CRCN / project leader)
aurore.claude-taupin@inserm.fr
Dr Cédric DELEVOYE
(INSERM DR2 / project leader)
cedric.delevoye@inserm.fr
Dr Quentin FRENGER
(postdoctoral researcher)
quentin.frenger@inserm.fr
Dr Maribel LARA CORONA
(postdoctoral researcher)
maribel.lara-corona@inserm.fr
Dr Maria-Laura ROJAS
(postdoctoral researcher)
maria-laura.rojas@inserm.fr
Dr Laura SALAVESSA
(postdoctoral researcher)
laura.salavessa@inserm.fr
Carla ALEMANY
(PhD student)
carla.alemany@inserm.fr
Dobrawa AMIRI
(PhD student)
dobrawa.amiri@inserm.fr
Flavie GARAMPON
(PhD student)
flavie.garampon@inserm.fr
Myckaëla ROUABAH
(PhD student)
myckaela.rouabah@inserm.fr
Keywords
Membrane dynamics, organelles, endolysosomal system, phospholipids, autophagy, stress, kidney and skin physiology/physiopathology
Description
Our research explores how mammalian cells adapt to environmental stresses by mobilizing organelles, endomembrane signaling platforms, and autophagic machinery. Through a combination of cellular and molecular biology, biochemical and microscopy approaches, we define how cells respond to nutrient fluctuations, mechanical forces, infections, or solar UV exposure through dynamic changes in cellular membranes and associated components.
3 main recent PUBLICATIONS:
Morphodynamical adaptation of the endolysosomal system to stress
Da Graça et al., FEBS Letter. 2024
Lien: DOI : 10.1111/febs.17154
The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells
Claude-Taupin et al., Nat Com. 2023
Lien: DOI : 10.1038/s41467-023-43775-1
A SNX1-SNX2-VAPB partnership regulates endosomal membrane rewiring in response to nutritional stress
Da Graça et al., Life Sci Alliance. 2022
Lien: DOI : 10.26508/lsa.202201652
Biological models
eukaryotic cell lines (e.g., kidney, skin), primary epidermal cells and pigmentation cell model, stress-induced cell system (shear stress, nutrient starvation, UV irradiation)