Restoring cellular copper homeostasis in Alzheimer disease: a novel peptide shuttle is internalized by an ATP-dependent endocytosis pathway involving Rab5- and Rab14-endosomes
Okafor, et al. 2024
View the publicationInstitute of Cellular and Integrative Neuroscience , UPR3212, Strasbourg
Team
Intracellular membrane trafficking in the nervous and neuroendocrine systems
Members
Nicolas Vitale - vitalen@unsitra.fr
Stéphane Gasman - sgasman@unistra.fr
Stéphane Ory - ory@unistra.fr
Sylvette Chasserot - chasserot@unistra.fr
Petra Tóth - petra.toth@unistra.fr
Emeline Tanguy - e.tanguy@unistra.fr
Keywords
lipids, secretory vesicle, exocytosis, endocytosis, phospholipase D, scramblases, cytoskeleton, membrane contact sites, leptin
Description
To control physiological processes and maintain homeostasis in the body, the nervous and neuroendocrine systems release hormones and neurotransmitters through regulated exocytosis. Our research aims to decipher the molecular mechanisms that regulate membrane trafficking and their dysfunction in pathologies such as intellectual disabilities, neurodegenerative diseases, neuroendocrine cancers, and obesity. We primarily focus on the role of lipids and key proteins that regulate the life cycle of secretory vesicles, from vesicle biogenesis to membrane fusion, including their intracellular transport.
Biological models
chromaffin cells, neurons, microglia, pheochromocytoma
Scientific Publications
Phospholipid Scramblase 1 Controls Efficient Neurotransmission and Synaptic Vesicle Retrieval at Cerebellar Synapses
Caputo, et al. 2024
View the publication